SMILE Study

A study testing a steroid mouthwash to help prevent mouth sores during chemotherapy.

The SMILE Study is researching whether a dexamethasone mouthwash can help reduce mouth sores caused by chemotherapy. Mouth sores, also called oral mucositis, can make it painful to eat, drink, speak, and continue cancer treatment. Researchers hope this study will help improve comfort and quality of life for patients receiving chemotherapy.

Participants in the study will use a steroid mouthwash several times each day while receiving chemotherapy. The study team will monitor participants for mouth soreness, treatment side effects, and how well the mouthwash is tolerated. Participants will also complete short questionnaires during treatment visits about symptoms and daily activities such as eating and speaking.

Researchers will compare the experiences of participants using the mouthwash with past patients who received similar chemotherapy without the mouthwash. Risks are expected to be low but may include mild mouth irritation, changes in taste, or oral yeast infection (thrush).

This study enrolls by invite only.